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F5421
Sigma
Anti-Fibroblast Growth Factor Receptor-1 antibody produced in rabbit
affinity isolated antibody, buffered aqueous solution
| Synonym: | Anti-FGFR-1 |
| MDL number: | MFCD00675556 |
Description
| Immunogen | synthetic peptide corresponding to amino acids 360-373 of the extracellular region of human FGF receptor-1 (FGFR-1, Flg). |
| Specificity | No reaction with FGFR-2 (Bek) and FGFR-3 is detected. |
| Physical form | Solution in 0.01 M phosphate buffered saline, pH 7.4, containing 1% bovine serum albumin and 15 mM sodium azide. |
Properties
| antibody form | affinity isolated antibody |
| clone | (polyclonal) |
| form | buffered aqueous solution |
| mol wt | antigen mol wt 110-120 kDa |
| species reactivity | human |
| application(s) | immunoblotting: 1:400 using an extract of FGFR-1 transfected cells |
| immunohistochemistry (formalin-fixed, paraffin-embedded sections): 1:200 using trypsin-digested human and animal tissue sections | |
| immunoprecipitation: suitable | |
| Gene Information | human ... FGFR1(2260) |
| shipped in | dry ice |
| storage temp. | −20°C |
Safety
| WGK Germany | 3 |
References
| reference | Griep, A., and Stolen, C., Disruption of lens fiber cell differentiation and survival at multiple stages by region-specific expression of truncated FGF receptors. Dev. Biol. 217, 205-220, (2000) Abstract |
| Jing, X., et al., Fibroblast growth factor 23 reduces expression of type IIa Na+/Pi co-transporter by signaling through a receptor functionally distinct from the known FGFRs in opossum kidney cells. Genes Cells 10, 489-502, (2005) Abstract | |
| Hall, H., and Hubbell, J., Matrix-bound sixth Ig-like domain of cell adhesion molecule L1 acts as an angiogenic factor by ligating αβ3-integrin and activating VEGF-R2. Microvasc. Res. 68, 169-178, (2004) Abstract |
